The study of lipid profile, LP (a) and electrolytes with oxidative stress, total protein and albumin in nephrotic syndrome

Hyperlipidemia is a common feature of the nephrotic syndrome. Hyperlipidemia so commonly complicates with heavy proteinuria that it has come to be regarded as an integral features of nephrotic syndrome lipid abnormalities in patients with the nephrotic syndrome have been recognized. 2 Lipoprotein abnormalities of the nephrotic syndrome are assumed to be related to the presence of proteinuria and risk for CHD. 3,4 The nephrotic syndrome is associated with an expanded interstitial volume and edema due to the Na and water retention. 5 The pathogenesis, clinical significance, and treatment options of the disturbances in lipid metabolism in adults with persistent nephrotic syndrome are reviewed. The lipoprotein profile is characterized by elevations of total plasma cholesterol and often triglycerides, elevated very low-density lipoprotein and low-density lipoprotein cholesterol, whereas high-density lipoprotein-cholesterol levels are variable; plasma levels of the atherogenic and thrombogenic lipoprotein (a) are also elevated. 6